Science will never
replace healthy lifestyle
But it can play a major supporting character to great lifestyle habits and don’t let anybody tell you otherwise. Proper nutrition, resistance exercise, good sleep, meaningful relationships, and even brain stimulation are all important lifestyle habits that should be advised. But there are ways to enhance those healthy choices you’re making even further. Here’s the science and literature we follow
Maintain Your
Healthy Weight
GLP-1s have made headlines in both positive and negative light. There’s no question about the effectiveness of weight loss using these drugs. But did you know that weight loss was only a happy side effect?
When utilized effectively, GLP1s can start the longevity journey
for you in several ways
This study concluded that: “there are evidences that GLP-1RAs and their analogs can enhance bone density and improve bone quality. GLP-1RAs and their analogs may play an anti-osteoporosis role by promoting bone formation and inhibiting bone absorption.
Xie B, Chen S, Xu Y, Han W, Hu R, Chen M, Zhang Y, Ding S. The Impact of Glucagon-Like Peptide 1 Receptor Agonists on Bone Metabolism and Its Possible Mechanisms in Osteoporosis Treatment. Front Pharmacol. 2021 Jun 14;12:697442. doi: 10.3389/fphar.2021.697442. PMID: 34220521; PMCID: PMC8243369
Muscle health is incredibly important for any longevity plan as it provides protection, and will improve immune function. This study concluded that “LP-1 infusion potently expands muscle microvascular surface area, increases muscle delivery and uptake of insulin, and improves insulin’s metabolic action in both acute and chronic insulin-resistant states. This may contribute to improved glycemic control seen clinically in diabetic patients receiving incretin-based therapies and afford potential to improve tissue/organ function and reduce morbidity and mortality associated with diabetes via microvascular recruitment and increased tissue perfusion.
Chai W, Zhang X, Barrett EJ, Liu Z. Glucagon-like peptide 1 recruits muscle microvasculature and improves insulin’s metabolic action in the presence of insulin resistance. Diabetes. 2014 Aug;63(8):2788-99. doi: 10.2337/db13-1597. Epub 2014 Mar 21. PMID: 24658303; PMCID: PMC4113068
Any longevity plan must address sleep especially in those patients with obstructive sleep apnea which often goes undiagnosed. This study concluded that “Given the high percentage of underdiagnosed sleep apnea in patients with diabetes and/or obesity, early initiation of GLP-1RA medication therapy can have superior benefits and reduce the need for polypharmacy especially in older individuals with multimorbidity.
Sultana R, Sissoho F, Kaushik VP, Raji MA. The Case for Early Use of Glucagon-like Peptide-1 Receptor Agonists in Obstructive Sleep Apnea Patients with Comorbid Diabetes and Metabolic Syndrome. Life (Basel). 2022 Aug 12;12(8):1222. doi: 10.3390/life12081222. PMID: 36013401; PMCID: PMC9410036
Leaky gut is often the cause of low-grade and chronic inflammation which must be addressed long term for those patients who are interested in a complete longevity plan. This study concluded that “The beneficial effects of GLP-1 have been attributed to its roles in improving intestinal barrier functions through stimulating crypt cell fission, downregulating proinflammatory cytokines by immune cells, and modulating gut microbiota.
Abdalqadir N, Adeli K. GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk. Microorganisms. 2022; 10(10):2061. https://doi.org/10.3390/microorganisms10102061
“Ozempic™ Babies” is a quickly trending term in patients, and it’s no surprise why. This study concluded that “the weight loss effects of GLP-1 RA offer a unique opportunity to expand the treatment options available to PCOS patients. This may be extremely useful under some circumstances, such as in assisted reproductive settings when women seeking help for infertility have advanced age and/or poor ovarian reserve. Moreover, these women, being overweight/obese, carry higher risks during controlled ovarian stimulation and throughout pregnancy, which can be minimized by a pretreatment with the specific goal to significantly reduce body weight.”
Cena H, Chiovato L, Nappi RE. Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists. J Clin Endocrinol Metab. 2020 Aug 1;105(8):e2695–709. doi: 10.1210/clinem/dgaa285. PMID: 32442310; PMCID: PMC7457958
Depression is a biochemical result of several potential factors, with one of the main causes being neuroinflammation. This study concluded that “ GLP-1 is a useful therapeutic modulator of depression, suggesting that abnormal alteration of neurotransmitter levels in the depressive brain results in mood impairment and cognitive decline…we reviewed the role GLP-1 in promoting neuronal differentiation and neural stem cell proliferation in the depressive brain.”
In addition, they found that “GLP-1 is a promising target for the treatment of depression because impaired neurogenesis ability and the reduction of neuronal differentiation leads to multiple depressive pathological symptoms…GLP-1 can enhance cognitive decline by improving synaptic function in the depressive brain. GLP-1 ameliorates synaptic dysfunction in the depressive brain and subsequently leads to the enhancement of cognitive function.
Kim YK, Kim OY, Song J. Alleviation of Depression by Glucagon-Like Peptide 1 Through the Regulation of Neuroinflammation, Neurotransmitters, Neurogenesis, and Synaptic Function. Front Pharmacol. 2020 Aug 14;11:1270. doi: 10.3389/fphar.2020.01270. PMID: 32922295; PMCID: PMC7456867
This is especially important in a complete longevity plan as prevention is the best medicine. This study found that “GLP-1 is able to modulate innate immune response in a number of inflammatory diseases.” The study evaluated this against diabetes, cardiovascular disease, disorders of the nervous system, tumors, and asthma.
Chen J, Mei A, Wei Y, Li C, Qian H, Min X, Yang H, Dong L, Rao X, Zhong J. GLP-1 receptor agonist as a modulator of innate immunity. Front Immunol. 2022 Dec 8;13:997578. doi: 10.3389/fimmu.2022.997578. PMID: 36569936; PMCID: PMC9772276
Cardiovascular disease is still the leading cause of mortality in the United States, so it’s no question that cardiovascular issues must be addressed in a complete longevity protocol. This study found that “GLP-1RAs are a class of agents with pleiotropic activities additional to the lowering of blood glucose. These pleiotropic effects include the reduction of BW and BP, the improvement of lipid metabolism and a spectrum of cardioprotective effects.
Ma X, Liu Z, Ilyas I, Little PJ, Kamato D, Sahebka A, Chen Z, Luo S, Zheng X, Weng J, Xu S. GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential. Int J Biol Sci. 2021 May 11;17(8):2050-2068. doi: 10.7150/ijbs.59965. PMID: 34131405; PMCID: PMC8193264
These critical neurodegenerative diseases are often directly caused by years of poor nutritional choices. In this random, placebo-controlled, double blind clinical trial, it was concluded that “In AD patients with long-standing disease, 26 weeks of liraglutide treatment prevented the expected decline of CMRglc (glucose metabolism) that reflects disease progression, as observed in the placebo group.
Gejl M, Gjedde A, Egefjord L, Møller A, Hansen SB, Vang K, Rodell A, Brændgaard H, Gottrup H, Schacht A, Møller N, Brock B, Rungby J. In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial. Front Aging Neurosci. 2016 May 24;8:108. doi: 10.3389/fnagi.2016.00108. PMID: 27252647; PMCID: PMC4877513
It has been further studied that GLP-1s are actually a neuroprotectant with reduced glucose uptake in the brain.
Femminella GD, Edison P. Evaluation of neuroprotective effect of glucagon-like peptide 1 analogs using neuroimaging. Alzheimers Dement. 2014 Feb;10(1 Suppl):S55-61. doi: 10.1016/j.jalz.2013.12.012. PMID: 24529526
Next Step:
What Are Your Concerns?
Improve Your Hormones
Improve Your Body
Improve Your
Hormonal Balance
With Sermorelin
Human growth hormone (hGH or GH) is a protein produced in the body that plays a crucial role not only in childhood but also throughout adulthood. GH is produced by the pituitary gland, often referred to as the “master gland” because it secretes numerous hormones that regulate the activities of other glands. The hypothalamus, a region in the brain, signals the pituitary gland to produce GH. Once released, GH travels through the bloodstream to perform its functions in various parts of the body.
Although the primary role of Growth Hormone (GH) is to facilitate growth during childhood, it remains crucial in adulthood. For both adults and children, GH plays a vital role in regulating metabolism, the essential process by which the body converts food into energy, tissues, or waste.
GH is involved in molecule transport, sugar conservation, protein synthesis, and fat breakdown. The GH produced by your body is essential not only for maintaining a healthy body composition but also for ensuring proper bone density, heart muscle function, and healthy cholesterol ratios. These functions are important for reducing the risk of conditions such as high cholesterol and osteoporosis.
Therefore, adults, like children, must maintain adequate GH levels. Insufficient GH in adults can lead to an increased risk of serious health issues, including cardiovascular and bone diseases, later in life.
REMEMBER: It’s not about having MORE GH that’s important in longevity, it’s about having the right balance of hormones for YOU.
Get Started Today
Improve Your Body Composition
With LeuSynergy™
LeuSynergy™ is an exercise and caloric restriction mimetic that improves Airtuin and NAD+ functions. This low-dose leucine compound is best known for its incredible enhancement of weight loss with GLP1s like semaglutide and tirzepatide.
LeuSynergy + GLP 1s has become a foundational pairing for body composition and metabolism optimization.
Cellular Pathway of LeuSynergy™
Delivering the right dose of Leucine decreases the amount of NAD needed to activate SIRT-1 (the longevity genes).
With Leucine, LESS NAD+ is needed for SIRT-1 functions and improving NAD+ utilization in other cellular pathways.
Why This Matters
SIRT-1 Activation stimulates caloric restriction and exercise pathways through these genetic factors:
- PGC-1a: The core regulator of mitochondrial biogenesis
- PPARγ: Regulates fat use
- AMPK: Master regulator of cell energy
- NF-kB: Inhibition leads to decreased inflammation and oxidative stress
Clinical Studies
Leucine-Resveratrol Synergy
Human Pre=diabetic Subjects Randomized
Leucine 11g+Resveratrol 50mg Twice Daily vs. Placebo
- Reduced insulin resistance for 33%
- Significant Improvement and insulin/glucose dynamics
Lipps J, Hagan S, Clark M, Davis D, Stone L, Survant L, et al.: Resveratrol synergy in pre-diabetes. Diabetes 2013;62: Poster 78-LB
Weight Loss – Fat Oxidation – Insulin Sensitivity
- placebo
- Leu-Pyr
- Loss of waist circumference vs. placebo at 4 weeks
- 82% more weight loss vs. placebo 12 at 12 weeks
- 2x the fat tissue loss vs. placebo
Synergy with GLP-1s: Semaglutide, Tirzepatide, Liraglutide
Studies show 15% reduction in body weight when semaglutide was accompanied by caloric restriction and exercise. Using an exercise mimetic like LeuSynergy is foundational in weight loss and metabolic health outcomes.
Insulin Independent Pathways for Glucose Disposal
GLP-1: Increase in GLUT4 expression by activating AMPK
LeuSynergy: Increase in GLUT4 expression through SIRT1 deacetylation of PGC-1a
Improved Fat Oxidation
GLP-1: Direct effects on hepatocytes by activating genes involved in beta-oxidation of fatty acids
LeuSynergy: Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylation
Oxidative Stress and Pancreatic Beta Cell Protection
GLP-1: Reduced oxidative stress in pancreatic islets. Increases B-cell mass by regulating cell kinectics and suppressing oxidative and ER stress, and amerlioration of glucolipotoxicity.
LeuSynergy: SIRT1 deacetylation and inhibition of NF-kB protecting beta cells from oxidative stress and inflammatory cytokines.
References:
- Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058.
- Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123(7):2764-2772. doi:10.1172/JCI67227
- Lan F, Weikel KA, Cacicedo JM, Ido Y. Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients. 2017 Jul 14;9(7):751. doi:10.3390/nu9070751. PMID: 28708087; PMCID: PMC5537865.
- Kitada M, Ogura Y, Monno I, Koya D. Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function. Front Endocrinol (Lausanne). 2019;10:187. Published 2019 Mar 27. doi:10.3389/fen-do.2019.00187
- Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol. 2020;11:1225. Published 2020 Aug 7. doi:10.3389/fphar.2020.012
Coming Soon
- Gut Health
- Brain Health
- Skin Health
- Sleep Health
- Heart Health
- Sexual Health
- Athletic Performance
