Improve Your Body Composition
With LeuSynergy™
LeuSynergy™ is an exercise and caloric restriction mimetic that improves Airtuin and NAD+ functions. This low-dose leucine compound is best known for its incredible enhancement of weight loss with GLP1s like semaglutide and tirzepatide.
LeuSynergy + GLP 1s has become a foundational pairing for body composition and metabolism optimization.
Cellular Pathway of LeuSynergy™
Delivering the right dose of Leucine decreases the amount of NAD needed to activate SIRT-1 (the longevity genes).
With Leucine, LESS NAD+ is needed for SIRT-1 functions and improving NAD+ utilization in other cellular pathways.
Why This Matters
SIRT-1 Activation stimulates caloric restriction and exercise pathways through these genetic factors:
- PGC-1a: The core regulator of mitochondrial biogenesis
- PPARγ: Regulates fat use
- AMPK: Master regulator of cell energy
- NF-kB: Inhibition leads to decreased inflammation and oxidative stress
Clinical Studies
Leucine-Resveratrol Synergy
Human Pre=diabetic Subjects Randomized
Leucine 11g+Resveratrol 50mg Twice Daily vs. Placebo
- Reduced insulin resistance for 33%
- Significant Improvement and insulin/glucose dynamics
Lipps J, Hagan S, Clark M, Davis D, Stone L, Survant L, et al.: Resveratrol synergy in pre-diabetes. Diabetes 2013;62: Poster 78-LB
Weight Loss – Fat Oxidation – Insulin Sensitivity
- placebo
- Leu-Pyr
- Loss of waist circumference vs. placebo at 4 weeks
- 82% more weight loss vs. placebo 12 at 12 weeks
- 2x the fat tissue loss vs. placebo
Synergy with GLP-1s: Semaglutide, Tirzepatide, Liraglutide
Studies show 15% reduction in body weight when semaglutide was accompanied by caloric restriction and exercise. Using an exercise mimetic like LeuSynergy is foundational in weight loss and metabolic health outcomes.
Insulin Independent Pathways for Glucose Disposal
GLP-1: Increase in GLUT4 expression by activating AMPK
LeuSynergy: Increase in GLUT4 expression through SIRT1 deacetylation of PGC-1a
Improved Fat Oxidation
GLP-1: Direct effects on hepatocytes by activating genes involved in beta-oxidation of fatty acids
LeuSynergy: Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylation
Oxidative Stress and Pancreatic Beta Cell Protection
GLP-1: Reduced oxidative stress in pancreatic islets. Increases B-cell mass by regulating cell kinectics and suppressing oxidative and ER stress, and amerlioration of glucolipotoxicity.
LeuSynergy: SIRT1 deacetylation and inhibition of NF-kB protecting beta cells from oxidative stress and inflammatory cytokines.
References:
- Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058.
- Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123(7):2764-2772. doi:10.1172/JCI67227
- Lan F, Weikel KA, Cacicedo JM, Ido Y. Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients. 2017 Jul 14;9(7):751. doi:10.3390/nu9070751. PMID: 28708087; PMCID: PMC5537865.
- Kitada M, Ogura Y, Monno I, Koya D. Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function. Front Endocrinol (Lausanne). 2019;10:187. Published 2019 Mar 27. doi:10.3389/fen-do.2019.00187
- Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol. 2020;11:1225. Published 2020 Aug 7. doi:10.3389/fphar.2020.012
